Sağlıklı Bireylerden ve Candida – İlişkili Protez Stomatitili Hastalardan İzole Edilmiş Stok C.albicans Suşları Arasındaki C.dubliniensis Prevalansının Moleküler Yöntemlerle Retrospektif Olarak Araştırılması

Objectives: Candida-related denture stomatitis (C-RDS), is the most frequent form of oral candidiasis, being detected in approximately 50%-65% denture-wearing patients. Candida albicans has been shown to be principal species responsible for inflammatory pathology. dubliniensis, first described Dublin 1995, was found very similar C. terms phenotypic features and type lesion it causes. It necessary determine historical prevalence C.dubliniensis due possibility that strains identified as C.albicans past years were C.dubliniensis. Materials Methods: In this study, 81 yeast isolated from samples only by photypic methods kept stock collection until 2003 re-examined molecular methods. Results: genotypic examination performed polymerase chain reaction restriction endonuclease reactions, 4 (8.8%) 45 healthy individuals C.dubliniensis, but all 36 patients with C-RDS C.albicans. Conclusions: As a result retrospective among orally 4.9%, not effective pathogenesis C-RDS.